Validated ASCVD/CKD calculators plus exploratory multi-disease risk curves.
Advanced CKD labs for KFRE 8-variable (optional but recommended)
Family history is a broad proxy for early or first-degree cardiometabolic/cancer history. Inputs are educational and not diagnostic.
ASCVD PCE (2013 + revised 2018), KDIGO CKD staging, and KFRE kidney failure risk.
In G1-G2, CKD diagnosis requires persistent kidney damage markers (for example albuminuria) or structural abnormalities.
PCE uses White-cohort equations for non-Black groups here; calibration may differ by ancestry/population.
KFRE is generally used for CKD populations (often eGFR <60 and/or significant albuminuria).
Risk shown assumes current profile remains stable over time. For education only, not medical diagnosis.
ACC ASCVD Risk Estimator Plus (PCE input ranges and clinical use)
Goff et al. 2013 ACC/AHA cardiovascular risk guideline (PCE derivation/use) — PubMed
Yadlowsky et al. revised pooled cohort equations (Ann Intern Med 2018) — PubMed
PooledCohort R package source (PCE 2013 and revised 2018 coefficients)
KDIGO 2024 CKD guideline (staging and risk stratification)
kfre R package source (KFRE 4/6/8-variable equations)
Tangri et al. kidney failure risk equation (JAMA, PubMed)
WHO cardiovascular diseases fact sheet
CDC stroke risk factors and prevention
NHLBI heart failure overview and risk factors
CDC type 2 diabetes risk factors
CDC chronic kidney disease basics and risks
Lancet Commission 2024 on dementia prevention (PubMed)
WCRF colorectal cancer prevention and risk factors
CDC lung cancer basics and risk factors
CDC cholesterol overview (LDL and heart disease/stroke links)
Note: The validated calculator card above uses published ASCVD PCE and KFRE equations plus KDIGO CKD staging logic. The multi-disease risk curves below remain evidence-informed exploratory estimates and are not clinical decision support.
Detailed model-to-source mapping: docs/MODEL_REFERENCES.md